Changes

| base = carbamazepine

| add = lamotrigine

==General information==

* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by

carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>