Difference between revisions of "Combining-Carbamazepine-Lamotrigine"

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| base = carbamazepine
 
| base = carbamazepine
 
| add = lamotrigine
 
| add = lamotrigine
}}
+
| cave = Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by
==General information==
+
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
 +
| info =  
 
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
 
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
 
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
 
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
 
+
| start =  
==Combination==
 
 
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
 
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
 
+
}}
==Caution==
 
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by
 
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
 

Revision as of 16:39, 3 March 2010

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to carbamazepine.

Infobord.png General information
  
Carbamazepine
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  
Lamotrigine
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  
Carbamazepine
  
Lamotrigine
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
Eenrichtingbord.png Start lamotrigine
  
Lamotrigine
  • Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
Nietinrijdenbord.png Stop lamotrigine
  
Lamotrigine
Letopbord.png Cave

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [6]


  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. 3.0 3.1 Farmacotherapeutisch Kompas - carbamazepine (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  4. KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
  5. Drugs.com lamotrigine
  6. [http://www.ncbi.nlm.nih.gov/pubmed/12648898 Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1]
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