Changes

| info =&nbsp;| metabolites_ref = '''General information''' =<ref name="informatorium">{{KNMP|carbamazepine}} </ref>* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. == '''Combination''' ==| start =* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice. == '''Caution ''' ==Abrupt stop Dose adjustment of carbamazepine can cause serious is not necessary when lamotrigine rash as lamotrigine levels increaseis added. <ref name="torrentcfreeman"> {{Pubmed|126488989433333|Koch HJ Freeman et al. Clinically relevant reduction Mood stabilizer Combinations: A Review of lamotrigine concentrations by carbamazepineSafety and Efficacy. Am J Clin Psychiatry 20051998;66155:40012-21}}</ref> <ref name="drugscomint">{{Drugscominteract|lamotrigine-with-carbamazepine-11430-0-497-0|lamotrigine|carbamazepine}}</ref>| cave = {{CombiCaLa}}