Changes

| cave info = &nbsp;| metabolites_ref = Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentcinformatorium"> {{Pubmed|12648898KNMP|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>| info = * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.

* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.Dose adjustment of carbamazepine is not necessary when lamotrigine is added.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref> <ref name="drugscomint">{{Drugscominteract|lamotrigine-with-carbamazepine-1430-0-497-0|lamotrigine|carbamazepine}}</ref>| cave = {{CombiCaLa}}