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Combining-Carbamazepine-Lamotrigine

329 bytes removed, 15:05, 22 June 2010
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| base = carbamazepine
| add = lamotrigine
| info = &nbsp;* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.| metabolites_ref = <ref name="informatorium">{{KNMP|carbamazepine}} </ref>
| start =
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.* Lamotrigine may increase levels Dose adjustment of carbamazepine metabolitesis not necessary when lamotrigine is added.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy.Am J Psychiatry 1998;155:12-21}}</ref> <ref name="drugscomint">{{Drugscominteract|lamotrigine-with-carbamazepine-1430-0-497-0|lamotrigine|carbamazepine}}</ref>
| cave =
* Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1CombiCaLa}}</ref>
}}
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