Difference between revisions of "Combining-Carbamazepine-Lamotrigine"

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(Created page with '{{Drugcombi | base = carbamazepine | add = lamotrigine == '''General information''' == * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent in...')
 
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| base = carbamazepine
 
| base = carbamazepine
 
| add = lamotrigine
 
| add = lamotrigine
== '''General information''' ==
+
 
 +
| General information =
 
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
 
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
 
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
 
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
  
== '''Combination''' ===
+
| Combination =
 
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
 
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
  
== '''Caution ''' ==
+
| Caution =
 
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by  
 
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by  
 
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
 
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
  
 
}}
 
}}

Revision as of 15:25, 3 March 2010

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.




  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. 3.0 3.1 Farmacotherapeutisch Kompas - carbamazepine (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
  5. Drugs.com lamotrigine
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