Combining-Carbamazepine-Lamotrigine

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Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
{{:lamotrigine

General information

  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.

Combination =

  • Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.

Caution

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5] }}

Adding lamotrigine

General information

  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.

Combination =

  • Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.

Caution

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5] to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.




  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
  5. [http://www.ncbi.nlm.nih.gov/pubmed/12648898 Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1]
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[[Category:Combi-lamotrigine

General information

  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.

Combination =

  • Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.

Caution

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5]]]