Open main menu

Psychiatrienet β

Combining-Carbamazepine-Lamotrigine

Revision as of 13:09, 22 April 2010 by Ashni (talk | contribs)
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
Eenrichtingbord.png Start lamotrigine
  • Add lamotrigine according to the general dosing advice.
Letopbord.png Cave
  • Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [6]
  • Carbamazepine can reduce lamotrigine serum concentration considerably.[7][8][9]
  • Lamotrigine may increase levels of carbamazepine metabolites. [7][8][9]


  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. 3.0 3.1 Farmacotherapeutisch Kompas - carbamazepine (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
  5. Drugs.com lamotrigine
  6. Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1
  7. 7.0 7.1 Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  8. 8.0 8.1 Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
  9. 9.0 9.1 Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.