Difference between revisions of "Combining-Gabapentin-Risperidone"

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* Gabapentine is eliminated unchanged by the kidney for 100%.
 
* Gabapentine is eliminated unchanged by the kidney for 100%.
 
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.  
 
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.  
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
+
* {{CombiBasic}}
 
| start =  
 
| start =  
 
* Start risperidone according to the general dosing advice.
 
* Start risperidone according to the general dosing advice.

Revision as of 12:05, 21 April 2010

Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to gabapentin.

Infobord.png General information
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Gabapentine is eliminated unchanged by the kidney for 100%.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [5]
Eenrichtingbord.png Start risperidone
  • Start risperidone according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [6]


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