Combining-Gabapentin-Valproic acid

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Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin
Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid

Adding valproic acid to gabapentin.

Infobord.png General information
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [4]
Eenrichtingbord.png Start valproic acid
  • Start valproic acid according to the general dosing advice.



  1. 1.0 1.1 Farmacotherapeutisch Kompas - gabapentine (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
  4. Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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