Difference between revisions of "Combining-Lithium-Carbamazepine"

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| add = carbamazepine
 
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* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
 
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
| start =  
 
| start =  

Revision as of 11:43, 21 April 2010

Lithium
Type moodstabilizer
Group other
links
ATC-code N05AN01
Medscape Lithium
PubChem 11125
PubMed Lithium
Drugs.com lithium
Kompas (Dutch) Lithium
Wikipedia Lithium
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to lithium.

Infobord.png General information
  • Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Start carbamazepine according to the general dosing advice.
Letopbord.png Cave
  • The combination may rarely cause neurotoxicity without increased plasma levels.


  1. 1.0 1.1 Farmacotherapeutisch Kompas - lithium (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  2. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  3. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
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