Difference between revisions of "Combining-Lithium-Gabapentin"

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(Created page with '{{Drugcombi | base = lithium | add = gabapentin | info = * Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects. * Gab...')
 
 
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| add = gabapentin
 
| info =  
 
| info =  
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.  
+
* The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding. Since there is little risk of drug interactions, use with lithium is likely to be safe. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
* Gabapentine is eliminated unchanged by the kidney for 100%.
 
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
 
 
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| start =  
 
* Start gabapentine according to the general dosing advice.
 
* Start gabapentine according to the general dosing advice.
 
| cave =  
 
| cave =  
 
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
 
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-gabapentin|lithium|gabapentin}}</ref>   
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{{Drugscominteract|lithium-with-gabapentin-1147-0-1477-0|lithium|gabapentin}}</ref>   
 
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Latest revision as of 11:59, 25 June 2010

Lithium
Type moodstabilizer
Group other
links
ATC-code N05AN01
Medscape Lithium
PubChem 11125
PubMed Lithium
Drugs.com lithium
Kompas (Dutch) Lithium
Wikipedia Lithium
Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin

Adding gabapentin to lithium.

Infobord.png General information
  
Lithium
  • Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
  
Gabapentin
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  
Lithium
  
Gabapentin
  • The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding. Since there is little risk of drug interactions, use with lithium is likely to be safe. [2]
Eenrichtingbord.png Start gabapentin
  
Gabapentin
  • Start gabapentine according to the general dosing advice.
Nietinrijdenbord.png Stop gabapentin
  
Gabapentin
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [3]


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