Difference between revisions of "Combining-Olanzapine-Quetiapine"

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* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
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Revision as of 08:10, 28 April 2010

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • From a pharmacotherapeutical point of view this combination is not very likely to occur.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start quetiapine
  • Start quetiapine according to the general dosing advice.
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive effects when used in combination. [6]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. NVZA; Toxicology.org; Monografie 73 (dutch)
  5. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  6. 6.0 6.1 Drugs.com quetiapine-fumarate Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
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