Difference between revisions of "Combining-Olanzapine-Risperidone"

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| add = risperidone
 
| add = risperidone
 
| info =  
 
| info =  
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
 
* There is no evidence published related to this drug combination recently. The combination will also have additive side effects.
 
 
| start =  
 
| start =  
* Start risperidone according to the general dosing advice.
+
{{IrrationalCombiAP}}
 
| cave =  
 
| cave =  
 
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
 
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
 
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>   
 
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>   
 
}}
 
}}

Latest revision as of 10:18, 25 June 2010

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Eenrichtingbord.png Start risperidone
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive effects when used in combination. [6]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. 5.0 5.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  6. Interactions between risperidone and olanzapine on drugs.com
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