Difference between revisions of "Combining-Quetiapine-Carbamazepine"

From Psychiatrienet
Jump to: navigation, search
 
Line 6: Line 6:
 
| start =  
 
| start =  
 
* Start carbamazepine according to the general dosing advice.
 
* Start carbamazepine according to the general dosing advice.
* The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
+
* The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.<ref name="drugscomint">
 +
{{Drugscominteract|carbamazepine-with-quetiapine-497-0-1979-0|carbamazepine|quetiapine}}</ref>
 
| cave =  
 
| cave =  
 
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
 
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
 
}}
 
}}

Latest revision as of 14:24, 18 June 2010

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to quetiapine.

Infobord.png General information
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Start carbamazepine according to the general dosing advice.
  • The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.[8]
Letopbord.png Cave
  • Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. [9]


The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.