Combining-Quetiapine-Carbamazepine

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Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to quetiapine.

Infobord.png General information
  
Quetiapine
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  
Carbamazepine
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  
Quetiapine
  
Carbamazepine
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  
Carbamazepine
  • Start carbamazepine according to the general dosing advice.
  • The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
Nietinrijdenbord.png Stop carbamazepine
  
Carbamazepine
Letopbord.png Cave
  • Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. [8]


  1. 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. Drugs.com quetiapine-fumarate
  5. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  6. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  7. Farmacotherapeutisch Kompas - carbamazepine (dutch)
  8. Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91
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