Combining-Quetiapine-Lamotrigine

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Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to quetiapine.

Infobord.png General information
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start lamotrigine
  • Start lamotrigine according to the general dosing advice.



  1. 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. 4.0 4.1 Drugs.com quetiapine-fumarate Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
  5. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  6. Farmacotherapeutisch Kompas - lamotrigine (dutch)
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