Difference between revisions of "Combining-Quetiapine-Olanzapine"

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| add = olanzapine
 
| add = olanzapine
 
| info =  
 
| info =  
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
 
| start =  
 
| start =  
* Start olanzapine according to the general dosing advice.
+
{{IrrationalCombiAP}}
 
| cave =  
 
| cave =  
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
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* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscominteract">
 
{{Drugscominteract|olanzapine-with-quetiapine-1979-1274-1744-1113|olanzapine|quetiapine}}</ref>   
 
{{Drugscominteract|olanzapine-with-quetiapine-1979-1274-1744-1113|olanzapine|quetiapine}}</ref>   
 
}}
 
}}

Latest revision as of 11:29, 25 June 2010

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to quetiapine.

Infobord.png General information
  
Quetiapine
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  
Olanzapine
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  
Quetiapine
  
Olanzapine
Eenrichtingbord.png Start olanzapine
  
Olanzapine
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Nietinrijdenbord.png Stop olanzapine
  
Olanzapine
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive effects when used in combination. [7]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. Drugs.com quetiapine-fumarate
  5. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  6. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  7. Interactions between olanzapine and quetiapine on drugs.com
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