Difference between revisions of "Combining-Risperidone-Carbamazepine"

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* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
 
* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
 
* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">
 
* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">
{{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>   
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{{Drugscominteract|risperidone-with-carbamazepine-497-0-2019-0|risperidone|carbamazepine}}</ref>   
 
| cave =  
 
| cave =  
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="drugscom">
+
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="drugscom" />
{{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>
 
 
}}
 
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Revision as of 23:42, 8 March 2010

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
  • Risperidone should be given at higher dosage to control psychotic symptoms. [7]
Letopbord.png Cave
  • Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. [7]


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