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Combining-Risperidone-Olanzapine

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Eenrichtingbord.png Start olanzapine
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive (side)effects when used in combination. [6]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  3. 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  4. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  5. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  6. Interactions between risperidone and olanzapine on drugs.com
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