Combining-Topiramate-Carbamazepine

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Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to topiramate.

Infobord.png General information
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Carbamazepine can increase topiramate clearance. Add carbamazepine according to the general dosing advice and check the effects of topiramate and increase dose if necessary. [5] [6]



  1. 1.0 1.1 1.2 Farmacotherapeutisch Kompas - topiramaat (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  2. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  3. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
  5. Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
  6. Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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