Adding risperidone to ziprasidone.
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- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
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- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- The concurrent use of ziprasidone with other medications that can prolong the QT interval is considered contraindicated.
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