Difference between revisions of "Dosulepine-nortriptyline"

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{{Drugswitch  
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{{Drugswitch
| from = dosulepine  
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| from = dosulepine
| to = nortriptyline  
+
| to = nortriptyline
 
| stop =  
 
| stop =  
* Gradually reduce dosage of dosulepine to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* When a dosage of 50 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of nortriptyline the next day in a normal dosage of 50 mg/day.
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{{TCAincrease25p3d}}
 
| info =
 
| info =
* {{TCAantichol}}
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{{TCAplasmalevelmonitoring}}
{{review}}
 
 
 
 
}}
 
}}

Latest revision as of 13:42, 30 June 2023

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from dosulepine to nortriptyline.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start nortriptyline
  • No wash-out period is needed.
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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