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Difference between revisions of "Doxepine-vortioxetine"

 
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| to = vortioxetine  
 
| to = vortioxetine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of doxepine to 50 mg/day.
+
| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of doxepine to 25 mg/day.
+
| info =
* '''Day 8:''' stop administration of doxepin.
+
* Safe target dose vortioxetine = 10 mg
| start =  
 
* '''Day 8:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
 
| info =  
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
{{review}}
 
 
}}
 
}}

Latest revision as of 11:22, 30 June 2023

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from doxepine to vortioxetine.[2] [3]

Nietinrijdenbord.png Stop doxepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start vortioxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose vortioxetine = 10 mg
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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