Difference between revisions of "Duloxetine-agomelatine"

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| to = agomelatine  
 
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* '''Before day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.  
+
* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.  
 
* '''Day 1:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
 
* '''Day 1:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
 
* '''Day 8:''' stop administration of duloxetine.
 
* '''Day 8:''' stop administration of duloxetine.

Revision as of 09:56, 17 November 2009

Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from duloxetine to agomelatine.[1] [2]

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
  • Day 8: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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