Difference between revisions of "Duloxetine-dosulepine"

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| to = dosulepine  
 
| to = dosulepine  
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of duloxetine to a maximum of 30 mg/day.
 
 
| start =  
 
| start =  
A wash-out period of one week is necessary.
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{{TCAincrease25p3d}}
* '''Day 1:''' simultaneously start administration of dosulepine in a low dosage of 25-50 mg/day.
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| info =
* '''Day 8:''' stop administration of duloxetine and increase the dosage of dosulepine to 50-75 mg/day.
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{{TCAplasmalevelmonitoring}}
| info =  
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}}
* Duloxetine slows the metabolism of dosulepine by CYP2D6.
 
* Caution is necessary at the start of administration of dosulepine. }}
 

Latest revision as of 13:49, 30 June 2023

Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from duloxetine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop duloxetine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start dosulepine
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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