Difference between revisions of "Duloxetine-hypericum"
From Psychiatrienet
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| − | * Occurrence of serotonin syndrome is | + | * Occurrence of serotonin syndrome is possible, so wash-out/caution is necessary.}} |
Revision as of 16:55, 15 July 2009
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Switch medication from duloxetine to hypericum.[1] [2]
Stop duloxetine - Before day 0: gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine to 30 mg/day.
- Day 8: stop administration of duloxetine.
Start hypericum- Day 8-11: a wash-out period of four days is necessary.
- Day 12: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
More information- Occurrence of serotonin syndrome is possible, so wash-out/caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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