Difference between revisions of "Fluoxetine-bupropion"

From Psychiatrienet
Jump to: navigation, search
 
(9 intermediate revisions by 4 users not shown)
Line 1: Line 1:
{{Drugswitch  
+
{{Drugswitch
 
| from = fluoxetine  
 
| from = fluoxetine  
 
| to = bupropion  
 
| to = bupropion  
 
| stop =  
 
| stop =  
* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
+
{{stopFluoxetine1}}
* When a dosage of 20 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
* '''Day 1:''' no administration of fluoxetine and bupropion (“wash-out” period of one day).
+
* '''Day 2:''' start administration of bupropion in a low dosage of 150 mg/day.
* '''Day 2:''' start administration of bupropion in a low dosage of 150 mg/day
+
* '''Day 30:''' if necessary gradually increase bupropion to 300 mg/day.
 +
 
 +
| info =
 +
* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
 +
{{longt1/2fluvox}}
 +
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
 +
 
 +
 
 +
 
 +
}}

Latest revision as of 11:25, 28 October 2015

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from fluoxetine to bupropion.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start bupropion
  • Day 2: start administration of bupropion in a low dosage of 150 mg/day.
  • Day 30: if necessary gradually increase bupropion to 300 mg/day.
Infobord.png More information
  • Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.