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Fluoxetine-maprotiline

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from fluoxetine to maprotiline.

Nietinrijdenbord.png Stop fluoxetine
  • Reduce the dosage to 20mg/day and then stop the administration
Eenrichtingbord.png Start maprotiline

Caution is necessary for at least four weeks.

  • Day 2: start administration of maprotiline in a low dosage of 25 mg/day.
  • Day 15: increase dosage of maprotiline to 50 mg/day.
  • Day 29: gradually increase dosage of maprotiline to 75 mg/day and more.
Infobord.png More information
  • Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Start low, go slow for maprotiline.
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