Difference between revisions of "Fluoxetine-sertraline"

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No wash-out period is needed.  
 
No wash-out period is needed.  
 
* '''Day 1:''' start sertraline the next day in low dosage of 25 mg/day.
 
* '''Day 1:''' start sertraline the next day in low dosage of 25 mg/day.
* '''Day 21:''' increase dosage of sertraline to normal, 50 mg/day.
+
* '''Day 14:''' increase dosage of sertraline to normal, 50 mg/day.
 
| info =  
 
| info =  
 
* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.  
 
* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.  
 
* {{theorSS}}
 
* {{theorSS}}
 
}}
 
}}

Revision as of 15:06, 27 November 2009

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from fluoxetine to sertraline.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start sertraline

No wash-out period is needed.

  • Day 1: start sertraline the next day in low dosage of 25 mg/day.
  • Day 14: increase dosage of sertraline to normal, 50 mg/day.
Infobord.png More information
  • Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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