Difference between revisions of "Fluoxetine-vortioxetine"

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* Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
 
* Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
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Latest revision as of 16:20, 21 October 2015

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from fluoxetine to vortioxetine.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day.
  • Day 1: stop administration
Eenrichtingbord.png Start vortioxetine
  • Day 1-21: A wash-out period is needed.
  • Day 22: Start vortioxetine in a dosage of 10 mg/day.
  • After day 28 : If necessary, increase gradually the dosage of vortioxetine.
Infobord.png More information
  • Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • This switch is currently being reviewed.
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