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Revision as of 16:46, 4 March 2015 by Roland (talk | contribs)
Type Antidepressant
Group SSRI
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Type Antidepressant
Group SMS
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from fluoxetine to vortioxetine.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
  • Day 1: when a dosage of 10 mg/day is reached, stop administration
Eenrichtingbord.png Start vortioxetine
  • A wash-out period is not necessary, but care is needed.
  • Day 1: start administration of vortioxetine in a dosage of 10 mg/day.
Infobord.png More information
  • Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.[1]
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