{{Drugswitch Drugswitchago

| stop = * {{StopSSRI,SNRI}}| start = * '''Day 1-7:''' a wash-out period of one week is necessary.* '''Day 8:''' simultaneously start administration of agomelatine after this period in a dosage of 25 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>* '''Day 11:''' If necessary, the increase dosage of agomelatine can be increased to 50 mg/day.

* Fluvoxamine stops inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>}}