{{Drugswitch Drugswitchago

| stop = {{StopSSRI,SNRI}}| start = * '''Before day Day 1:''' gradually reduce dosage simultaneously start administration of fluvoxamine to agomelatine in a maximum dosage of 50 25 mg/day, when this dosage is .<ref name="agoswitch"> 50 mg/day{{Pubmed|20196187|McAllister-Williams RH et al. * '''Day 1The use of antidepressants in clinical practice:''' reduce dosage of fluvoxamine further to 25 mg/dayfocus on agomelatine.* '''Day 8:''' stop administration of fluvoxamineHum Psychopharmacol.| start = * '''Day 8-142010 Mar 1;25(2):''' a wash95-out period of one week is necessary.102}}</ref>* '''Day 1511:''' start administration of agomelatine after this period in a dosage of 25 mg/day.* If necessary, the increase dosage of agomelatine can be increased to 50 mg/day.

* Fluvoxamine stops inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>