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Fluvoxamine-agomelatine

325 bytes added, 12:42, 4 August 2023
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| from = fluvoxamine
| to = agomelatine
| stop = {{stopFluvoxamineStopSSRI,SNRI}}| start = * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.<ref name="agoswitch"> {{StartAgomelatinePubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>* '''Day 11:''' If necessary, increase dosage of agomelatine to 50 mg/day.
| info =
* Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
{{SSRI14d}}
}}