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Difference between revisions of "Fluvoxamine-agomelatine"

 
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{{Drugswitch
+
{{Drugswitchago
 
| from = fluvoxamine  
 
| from = fluvoxamine  
 
| to = agomelatine  
 
| to = agomelatine  
| stop =  
+
| stop = {{StopSSRI,SNRI}}
* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.  
+
| start =
* '''Day 1:''' reduce dosage of fluvoxamine further to 25 mg/day.
+
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
* '''Day 8:''' stop administration of fluvoxamine.
+
* '''Day 11:''' If necessary, increase dosage of agomelatine to 50 mg/day.
| start =
 
* '''Day 8-14:''' a wash-out period of one week is necessary.
 
* '''Day 15:''' start administration of agomelatine after this period in a dosage of 25 mg/day.
 
* If necessary, the dosage of agomelatine can be increased to 50 mg/day.
 
 
| info =  
 
| info =  
* Fluvoxamine stops the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
+
* Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
{{review}}
 
 
}}
 
}}

Latest revision as of 11:42, 4 August 2023

Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from fluvoxamine to agomelatine.[1] [2] [3]

Nietinrijdenbord.png Stop fluvoxamine
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[4]
  • Day 11: If necessary, increase dosage of agomelatine to 50 mg/day.
Infobord.png More information
  • Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).[4]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. CBG meb, accessed august 2023,SmPC Valdoxan
  4. 4.0 4.1 McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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