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Fluvoxamine-clomipramine

Revision as of 14:43, 28 October 2015 by Anoek (talk | contribs)
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from fluvoxamine to clomipramine.[1] [2]

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine further to 25 mg/day.
  • Day 8: stop administration of fluvoxamine.
Eenrichtingbord.png Start clomipramine

Caution is necessary.

  • Day 1: simultaneously start administration of clomipramine in a low dosage of 25-50 mg/day.
  • Day 8: continue administration of clomipramine in a dosage of 50-75 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine slows the metabolism of clomipramine via CYP1A2 and CYP2D6.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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