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Fluvoxamine-imipramine

Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from fluvoxamine to imipramine.

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine further to 25 mg/day.
  • Day 8: stop administration of fluvoxamine.
Eenrichtingbord.png Start imipramine
  • Day 1: simultaneously start administration of imipramine in a low dosage of 25 mg/day.
  • Day 8: stop administration of fluvoxamine and continue administration of imipramine in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize imipramine.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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