Fluvoxamine-maprotiline

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Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from fluvoxamine to maprotiline.

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine further to 25 mg/day.
  • Day 8: stop administration of fluvoxamine.
Eenrichtingbord.png Start maprotiline
  • Day 1: simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.
  • Day 8: stop administration of fluvoxamine and continue administration of maprotiline. If necessary, increase dosage of maprotiline.
Infobord.png More information
  • Fluvoxamine slows the metabolism of maprotiline via CYP1A2 and CYP2D6.
  • "Start low, go slow" is not required, but caution is necessary.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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