* Administration of hypericum can be stopped abruptly.{{Stophyp}}| start = * '''Day 1-7:''' a wash-out period of one week is necessary.{{TCAincrease25p3d}}* '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day.* If necessary, increase dosage of amitriptyline to 50 mg/day.* Start low, go slow.| info = {{TCAplasmalevelmonitoring}}* Hypericum slows the metabolism The ratio of amitriptyline via CYP3A4/nortriptyline could change because of CPY2C19 induction. This effect may persist up Sum plasmalevels are not likely to two weeks after stopping hypericumm, so caution change because CYP2D6 is necessarybarely affected.{{caveSS}}{{HypericumInfo}}}}