Difference between revisions of "Hypericum-trazodone"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = trazodone | | to = trazodone | ||
| stop = | | stop = | ||
| − | * | + | * '''Day 1-14:'''Gradually decrease the dosage of hypericum. |
| − | | start = | + | * '''Day 15:''' stop administration of hypericum. |
| − | * '''Day | + | | start = |
| − | * '''Day | + | * '''Day 15-30:''' a wash-out period of at least two weeks is necessary. |
| − | + | * '''Day 31:''' start trazodone 100-150 mg/day. | |
| − | |||
| info = | | info = | ||
| − | * Occurrence of the serotonin syndrome is | + | * Occurrence of the serotonin syndrome is possible without wash-out period. |
| + | * Hypericum induces enzymes of the CYP P-450 type and P-gp. | ||
| + | * Hypericum probably has MAO-inhibiting properties.}} | ||
Revision as of 10:00, 15 July 2009
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Switch medication from hypericum to trazodone.[1] [2]
Stop hypericum - Day 1-14:Gradually decrease the dosage of hypericum.
- Day 15: stop administration of hypericum.
Start trazodone- Day 15-30: a wash-out period of at least two weeks is necessary.
- Day 31: start trazodone 100-150 mg/day.
More information- Occurrence of the serotonin syndrome is possible without wash-out period.
- Hypericum induces enzymes of the CYP P-450 type and P-gp.
- Hypericum probably has MAO-inhibiting properties.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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