Difference between revisions of "Imipramine-duloxetine"

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| to = duloxetine
 
| to = duloxetine
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
+
{{stopImipramine}}
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
 
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
 
 
| start =  
 
| start =  
 
* '''Day 4:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
 
* '''Day 4:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
 
* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine.
 
* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* {{theorSS}}
 
* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
 
* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
{{review}}
 
 
}}
 
}}

Latest revision as of 14:45, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from imipramine to duloxetine.

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of imipramine to 50 mg/day.
  • Day 4-7: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start duloxetine
  • Day 4: simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
  • Day 8: stop administration of imipramine and continue administration of duloxetine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
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