Imipramine-nortriptyline

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Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from imipramine to nortriptyline.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
  • When a dosage of 50-100 mg/day is reached, stop administration.
Eenrichtingbord.png Start nortriptyline
  • No wash-out period is needed.
  • Start administration of nortriptyline the next day in a normal dosage of 50 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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