Difference between revisions of "Imipramine-trazodone"

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| to = trazodone  
 
| to = trazodone  
 
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| stop =  
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
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{{stopImipramine}}
* '''Day 1:''' reduce dosage of imipramine to 25 mg/day.
 
* '''Day 8:''' stop administration of imipramine.
 
 
| start =  
 
| start =  
 
No wash-out period is needed.  
 
No wash-out period is needed.  
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* '''Day 8:''' continue administration of trazodone. {{upTrazo}}
 
* '''Day 8:''' continue administration of trazodone. {{upTrazo}}
 
| info =  
 
| info =  
* Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
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* {{theorSS}}
{{review}}
 
 
}}
 
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Latest revision as of 14:46, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from imipramine to trazodone.

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of imipramine to 50 mg/day.
  • Day 4-7: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start trazodone

No wash-out period is needed.

  • Day 4: simultaneously start administration of trazodone in a dosage of 150 mg/day.
  • Day 8: continue administration of trazodone. If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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