Difference between revisions of "Imipramine-vortioxetine"

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| to = vortioxetine  
 
| to = vortioxetine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
+
{{stopImipramine}}
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
 
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
 
* '''Day 8:''' stop administration of imipramine.
 
 
| start =  
 
| start =  
 
* A wash-out period is not necessary.
 
* A wash-out period is not necessary.
* '''Day 8:''' start administration of vortioxetine in a low dosage of 10 mg/day.
+
* '''Day 9:''' start administration of vortioxetine in a low dosage of 10 mg/day.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* {{theorSS}}
{{review}}
 
 
}}
 
}}

Revision as of 13:47, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from imipramine to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of imipramine to 50 mg/day.
  • Day 4-7: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start vortioxetine
  • A wash-out period is not necessary.
  • Day 9: start administration of vortioxetine in a low dosage of 10 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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