Maprotiline-citalopram

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Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from maprotiline to citalopram.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
  • Day 1: reduce dosage of maprotiline to 50 mg/day.
  • Day 7: reduce dosage of maprotiline to 25 mg/day.
  • Day 14: stop dosage of maprotiline.
Eenrichtingbord.png Start citalopram
  • Day 7: simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
  • Day 14: stop administration of maprotiline and continue administration of citalopram/escitalopram.
Infobord.png More information
  • Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes maprotiline.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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