| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 14:''' stop dosage of maprotiline.{{TCAdecrease25p3d}}| start = * '''Day 7:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.* '''Day 14:''' stop administration of maprotiline and continue administration of duloxetine.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose duloxetine = 60 mg* Duloxetine is a inhibitor of CYP2D6, which metabolizes maprotiline.}}