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Difference between revisions of "Maprotiline-paroxetine"

 
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| to = paroxetine
 
| to = paroxetine
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
+
{{downNortriptyline}}
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
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| start = {{startmapnorcyp2d6}}
* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.
 
* '''Day 14:''' stop dosage of maprotiline.
 
| start =  
 
* '''Day 7:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
 
* '''Day 14:''' stop administration of maprotiline and continue administration of paroxetine.
 
 
| info =  
 
| info =  
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.  
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
{{review}}
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* Safe target dose paroxetine = 20 mg 
 
}}
 
}}

Latest revision as of 16:50, 30 June 2023

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from maprotiline to paroxetine.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Day 1: reduce dosage to 50%.
  • Day 8: stop
Eenrichtingbord.png Start paroxetine
  • Day 8: Start with 50% of the target dose
  • Day 15: Increase dose to 100% of the target dose
  • Day 16 and after: Gradually increase dose as necessary
Infobord.png More information
  • Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
  • Safe target dose paroxetine = 20 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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