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Difference between revisions of "Maprotiline-sertraline"

 
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| to = sertraline  
 
| to = sertraline  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.
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| info =
* '''Day 14:''' stop dosage of maprotiline.
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* Safe target dose sertraline = 50 mg
| start =  
 
* '''Day 7:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.
 
* '''Day 14:''' stop administration of maprotiline and continue administration of sertraline in a dosage of 50-100 mg/day.
 
| info =
 
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes maprotiline. 
 
{{review}}
 
 
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Latest revision as of 11:48, 30 June 2023

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from maprotiline to sertraline.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start sertraline
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose sertraline = 50 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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