Mianserine-amitriptyline

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Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from mianserine to amitriptyline.

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Eenrichtingbord.png Start amitriptyline

No wash-out period is needed.

  • Day 1: simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
  • Day 8: stop administration of mianserine and continue administration of amitriptyline. If necessary, increase dosage of amitriptyline.
  • Start low, go slow.


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